Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.02.07 | Adrenal (1) | ECE2015

Urinary free cortisone as a potential biomarker in diagnosing patients with mild Cushing's syndrome

Trementino Laura , Concettoni Carolina , Martino Marianna , Marcelli Giorgia , Michetti Grazia , Boscaro Marco , Arnaldi Giorgio

Introduction: Urinary free cortisol (UFC) determination has suboptimal sensitivity (SE) and specificity (SP) especially in mild Cushing’s syndrome (CS).Aim: To determine the performance of UFC and its metabolite cortisone (UFE) measured using accurate assays such as HPLC and LC–MS/MS in diagnosing patients with CS.Patients and methods: Sixty-seven patients with CS were compared to 49 sex- and age-matched non-CS. UFF and U...

ea0035p19 | Adrenal cortex | ECE2014

Acute pasireotide suppression test in patients with Cushing's disease: a role in predicting long-term efficacy?

Trementino Laura , Marcelli Giorgia , Michetti Grazia , Concettoni Carolina , Boscaro Marco , Arnaldi Giorgio

Introduction: Pasireotide is a multireceptor-targeted somatostatin analogue effective in the treatment of patients with Cushing’s disease (CD) but associated with an increased risk of hyperglycaemia. We prospectively investigate the role of an acute pasireotide suppression test (PST) in predicting long-term response in CD.Methods: Eleven patients with CD (seven females, four males; mean age 45±17.3 years) received at 0900 h a single s.c. inject...

ea0035p46 | Adrenal cortex | ECE2014

Diagnostic performance of late-night salivary cortisol measured by automated chemiluminescenze immunoassay

Marcelli Giorgia , Brugia Marina , Concettoni Carolina , Trementino Laura , Michetti Grazia , Boscaro Marco , Arnaldi Giorgio

Context: Late-night salivary cortisol (LNSC) measurement has been promoted as an ideal screening test for the diagnosis of Cushing’s syndrome (CS). However, its performance using commercially available assays has not been widely evaluated and limited data are available on its use in population with chronic medical conditions.Aim: To compare the diagnostic performance of LNSC (routine use) in patients with CS and in a patients’s group with diffe...

ea0032p33 | Adrenal cortex | ECE2013

Salivary cortisol is a useful tool to assess the immediate response to pasireotide in patients with Cushing’s disease

Cardinaletti Marina , Trementino Laura , Concettoni Carolina , Marcelli Giorgia , Polenta Barbara , Spinello Maurizio , Boscaro Marco , Arnaldi Giorgio

Introduction: Pasireotide is a promising treatment option for patients with Cushing’s disease (CD). The measurement of salivary cortisol is useful for diagnosing hypercortisolism and monitoring patients with CD following pituitary surgery. It may also be a better index of cortisol secretion than serum cortisol or urinary free cortisol (UFC). We investigated the value of salivary cortisol in monitoring short-term efficacy of pasireotide in patients with CD.<p class="ab...

ea0032p45 | Adrenal cortex | ECE2013

Long-term efficacy of pasireotide in a patient with Cushing's disease and diabetes: results in the short term are not always predictive of long-term response

Trementino Laura , Cardinaletti Marina , Concettoni Carolina , Marcelli Giorgia , Boscaro Marco , Arnaldi Giorgio

The management of Cushing’s disease (CD) can be problematic, particularly when the disease persists following pituitary surgery. Here we report the case of a 55-year old woman with CD that persisted after repeat transsphenoidal surgery. The patient had an overt phenotype with facial rubeosis, central obesity with supraclavicular fat accumulation, cervical fat pad and proximal muscle weakness. She had received anti-hypertensive drugs and insulin for diabetes mellitus. Horm...

ea0056p58 | Adrenal cortex (to include Cushing's) | ECE2018

The diagnostic accuracy of increased late night salivary cortisol for Cushing’s Syndrome: a real-life prospective study

Ceccato Filippo , Marcelli Giorgia , Martino Marianna , Concettoni Carolina , Brugia Marina , Trementino Laura , Michetti Grazia , Arnaldi Giorgio

Introduction and aim: A prompt diagnosis of Cushing’s Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST); late night salivary cortisol (LNSC) and urinary free cortisol (UFC) are recommend, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).<p class="...

ea0037ep88 | Adrenal cortex | ECE2015

A single-centre 10-years experience with pasireotide in Cushing's disease: patients characteristics and outcome

Trementino Laura , Michetti Grazia , Angeletti Alessia , Marcelli Giorgia , Concettoni Carolina , Cardinaletti Marina , Polenta Barbara , Boscaro Marco , Arnaldi Giorgio

Introduction: Pasireotide is the first pituitary-directed drug approved for Cushing’s disease (CD). We report our 10-years experience with pasireotide in CD reviewing and analysing data about all the patients treated with pasireotide at our referral centre both in randomised trials and in clinical practice.Patients and methods: Twenty active CD patients were treated. Fourteen patients were treated with pasireotide in randomised trials and six patien...

ea0035p957 | Steroid metabolism and action | ECE2014

Role of clinical risk factors and polymorphisms in glucocorticoid receptor gene in the determining the risk of developing new-onset diabetes after kidney transplantation

Michetti Grazia , Trementino Laura , Marcelli Giorgia , Apolloni Gloria , Taruscia Domenica , Frasca Giovanni Maria , Boscaro Marco , Faloia Emanuela , Arnaldi Giorgio

Introduction: New onset diabetes after transplantation (NODAT) is a recognized metabolic complication of kidney transplantation: its rates at 12 months after transplantation is between 20 and 50% for kidney recipients and it is associated with increased risks of graft rejection, infection, cardiovascular disease and death. Transplant-specific risk factors for NODAT,such as corticosteroids and calcineurin inhibitors, play a dominant role in its pathogenesis. Furthermore polymor...